How would you summarize your study for a lay audience? Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause inflammation during an asthma ...

Mast cells are central effectors in asthma, acting as both initiators and amplifiers of airway inflammation. Residing in peribronchial tissues and the epithelium, they respond to immunoglobulin E (IgE ...

Joshua A. Boyce, MD, chief of the Division of Allergy and Clinical Immunology at Brigham and Women's Hospital, is the senior author of a paper published in Immunity, "Mast Cells Control Lung Type 2 ...

Asthma is the most common chronic airway disease worldwide, imposing substantial clinical, societal, and economic burden.

Jasper Therapeutics’ monoclonal antibody briquilimab is effective at preventing mast-cell induced anaphylaxis and asthma in mice, new data suggest. In an oral presentation and two posters at the ...

See more of our trusted coverage when you search. Prefer Newsweek on Google to see more of our trusted coverage when you search. New understanding of a receptor key to allergic responses and ...

Jasper Therapeutics, Inc. announced that it is presenting updated clinical data from its Phase 1b/2a BEACON study on briquilimab, an antibody therapy targeting c-Kit to treat mast cell-driven diseases ...

Please provide your email address to receive an email when new articles are posted on . Barzolvolimab is an anti-KIT monoclonal antibody, and mast cells need KIT to survive. Weekly hive and itch ...

Please provide your email address to receive an email when new articles are posted on . Evidence of systemic mast cell activation in the PROSPECTOR study was split into three categories. A REMA score ...

Genetically engineered CAR T cells expressing artificial receptor proteins are increasingly used in the clinic to boost the ...

New research in mice has shown that food-induced anaphylaxis is driven by distinct immune pathways involving inflammatory lipids called leukotrienes. The findings, published across two separate ...