Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health.

BackgroundMuch of what we know about biology comes from animal models, particularly mice. Applying these insights to humans, however, is not always ...

Aging alters DNA methylation, histone modifications, chromatin organization, and regulatory RNA activity, affecting gene ...

Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. "This is the first detailed study ...

A Genome Medicine study finds differential expression outperforms allele-specific analysis for most genes, while CRISPR ...

Sequencing the human genome was once thought to be the key to understanding genetic diversity and disease, but gene ...

A new study finds that the Alx4 gene shows divergent limb bud expression in chicken and mouse, yet its protein function ...

In biology classrooms, we often learn that genes are transcribed into mRNA, which is then translated into proteins—a tidy, linear process. But gene expression in living cells is far more intricate, ...

Understanding human biology requires more than mapping our genes—we must also understand how gene expression is regulated to guide healthy development, growth, and maintenance of our body systems over ...

Preclinical data demonstrate broad CNS biodistribution following ICV administration, a routinely performed neurosurgical procedure, reinforcing NGN-401's route of delivery strategy ...

Understanding human biology requires more than mapping our genes – we must also understand how gene expression is regulated to guide healthy development, growth, and maintenance of our body systems ...